1
عمومی::
متابولیسم دارو
Historically, population variability in drug metabolism or therapeutic response was described in terms of the observed phenotype, for example, slow metabolizers or sensitive responders.
During translation this results in the insertion of a proline instead of histidine at amino acid position 324 generating the CYP2D6*7 allele, with no drug metabolizing activity (The Human Cytochrome P450 Allele Nomenclature Database, 2014).
Deletion or inversion of entire genes on the chromosome would obviously have the opposite effect on enzyme activity and drug metabolism.
Genetic Polymorphism in Drug Metabolism
As discussed in Chapter 12, drug metabolism is responsible for the chemical modification of drugs or other xenobiotics that usually results in increased polarity to enhance elimination from the body.
واژگان شبکه مترجمین ایران